Friday, June 23, 2017



THE GLOG IS ONE-YEAR OLD !


Dear colleagues,


It is one year of the "Glaucoma Specialty Club", the glog which started with modest goals of interacting with fellow ophthalmologists and to provide professional information on glaucoma. Most websites provide information for patients and not for health-care professionals. Frequently, I surfed the world-wide web for a website which would cater to health-care providers but was unable to find one which could satisfy my thirst. "Glaucoma Specialty Club: The Glog", aspires to fill that gap and help every ophthalmologist interested in glaucoma.


During the last 1 year I tried to write about the fundamental principles guiding us in the understanding of glaucoma (anatomy of the ciliary body, aqueous production), certain types of glaucomas (lens induced), investigations pertinent to glaucoma (visual fields, anterior segment imaging) and also management of glaucoma (Ahmad's Modified Trabeculectomy Technique, complications of trabeculectomy) and so on. The idea was to keep every level of understanding represented in this interaction. 


I do not know to what extent I succeeded in my efforts. The positive messages I got from different people, the over 5000 visitors to the site from various countries extending from Malaysia, Japan, Russia, India, Pakistan, UAE, US, UK, Brazil, Argentina and so on made me humbled. This is the impetus which carries me forwards. 


I wish I could thank every visitor personally for visiting the glog, for the comments and support. For me this is the energy which keeps my passion burning and inspiring me to improve. There are already a few changes which have come up. The write-up part on the web-page has been made wider, the background has changed and there is a new logo. 


There are more plans being made to make some more changes in the near future. The glog aspires to continue its primary mission of imparting glaucoma related knowledge free and openly accessible to everyone. So, I look forward to see you all coming here regularly and guiding me. Adios for now!

-Syed Shoeb Ahmad
 

Friday, June 16, 2017

LATE POST-OPERATIVE COMPLICATIONS OF TRABECULECTOMY
(PART 2)
Late postoperative complications occur more than 4 weeks after surgery.


·         HIGH BLEB PHASE=
o   High IOP can occur transiently for 3-6 weeks after surgery. A succulent bleb and a gonioscopically unobstructed sclerostomy is present. On examination a diffuse, elevated and opalescent bleb with thickened subconjunctival connective tissue and paucity of microcysts is present. This transient IOP elevation is due to temporary swelling of sclera or the collagenous lining of the wall of the bleb (“high bleb phase”) which limits aqueous outflow.
o   Intermittent digital pressure can be applied to the lower lid. Aqueous suppressants can be given to reduce flow through the bleb as its walls remodel to ultimately allow improved outflow. Corticosteroid administration is also increased to prevent fibrosis.
o   The condition resolves in a few weeks when aqueous suppressants can be stopped.

·         FILTRATION FAILURE=
o   Gonioscopy should be done to rule out an obstructed internal sclerostomy. Any tissue blocking can be cut by argon or Nd:YAG laser.
o   Growth of fibrous tissue across the scleral surface is the commonest cause of glaucoma-filtering-surgery (GFS) failure. In some cases the conjunctiva and Tenon’s capsule form a thick walled (Tenon’s) cyst surrounding the sclerostomy. The cyst is characterized by a dome-like, tense, injected aqueous-filled space within the subconjunctiva. The overlying conjunctiva is mobile. A Tenon’s cyst or fibrous tissue growth across the scleral flap can be incised under visual control at the slit-lamp or operating microscope.
o   [In one technique described, 0.2mg/ml Mitomycin-C (MMC) (0.1 ml) and 1% lignocaine (0.1 ml) is injected adjacent to the bleb about 15-20 minutes prior to needling. A 27- to 30- gauge needle on a 1ml syringe filled with BSS is entered under the conjunctiva 2-3 mm from the cyst. The needle punctures the wall of the cyst to exit from the other side. If the bleb shows flat scarring in the subconjunctival tissues, then the needle is used to penetrate the scar tissue (“band of steel”) and lift the scleral flap. An injection of 5-FU can be given after the procedure.]
o   In a failed GFS, a trial of anti-glaucoma treatment is given. If surgery is deemed necessary, another GFS in a non-scarred area is done. Inferior trabeculectomies should be avoided as the failure rates are higher; they cause more irritation and have higher rates of blebitis and post-operative endophthalmitis (POE). In such a situation, tube insertion (Glaucoma Drainage Device) or trans-scleral cyclophotocoagulation (TSCPC) can be attempted.

·         CATARACT=
o   Cataracts can occur soon after surgery due to surgical trauma. They usually develop as a consequence of BSS hitting the lens from the side-port. This can be avoided by directing the side-port away from the centre.
o   Cataract surgery can cause functioning blebs to fail or shrink in size. A clear corneal temporal phacoemulsification should be done in such cases. Posterior synechiae and a miosed pupil may require additional manipulation to enlarge the pupil (e.g. iris hooks). Postoperatively IOP should be monitored closely and meticulous viscoelastic removal should be done intraoperatively to prevent any post-operative IOP spikes.



·         LATE BLEB LEAKS=
o   Most blebs show trans-conjunctival ooze characterized by a positive Seidel’s test. However, these blebs do not require any intervention. In some cases, especially where anti-metabolites have been used, a thin-walled, friable, avascular bleb may show a late leak. Such blebs have a higher risk of POE and hypotonic maculopathy.
o   Initial conservative treatment of bleb leaks include: pressure patch, topical antibiotic, aqueous humor suppressants and/or placement of a Simmon’s shell or an over-sized soft contact lens to compress the bleb defect. Some experts suggest placing tissue glue directly over the bleb defect or placing a patch on the hole. The glue should be covered with a large diameter CL or collagen shield to avoid glue related complications (corneal abrasion or epitheliopathy).
o   Direct suturing of the hole/defect might be difficult in avascular tissue, leading to tears of the conjunctiva. If sufficient Tenon’s capsule is present beneath the hole, a compression suture can be tried. Autologous blood injection into the bleb can also be attempted. Argon laser treatment can be done by manually apposing the wound edges while laser burns are applied to weld the edges together (200µ, 200mW, 0.5s). Another technique involves application of argon laser burns circumferentially around the defect after painting the area with Rose Bengal dye, which facilitates laser absorption into avascular tissues (200µ, 100-200mW, 0.05s). However, a persistent leak requires surgical resection and resuturing.

·         CHRONIC HYPOTONY=
o   Persistently low IOP ≤5 mm Hg is defined as chronic hypotony.
o   The causes include: Overfiltration, bleb leak, aqueous humor hyposecretion with/without choroidal detachment, iridocyclitis, cyclodialysis cleft, unrecognized retinal detachment, severe ocular ischemia.
o   Risk factors for hypotonic maculopathy: young age and myopia.
o   Fundus findings: Folding of choroid and overlying RPE of the posterior pole; swelling of the optic disc (unless atrophied or extensively cupped); increased tortuosity and engorgement of retinal vessels.
o   Management: Treat the cause (bleb leak, choroidal detachment, cyclodialysis cleft or retinal detachment). Aqueous suppressants which can cause late hypotony should be stopped. An extensively large and over-functioning bleb can be reduced by painting with trichloracetic acid; short exposure cryoapplication to the edges of the bleb; autologous blood injection within the periphery of bleb; Nd:YAG thermal delivery to the scleral surface or compression sutures. In case these techniques fail, bleb revision is required.


·        
 BLEB INFECTION (BLEBITIS)/ENDOPHTHALMITIS=
o   Late bleb infection/endophthalmitis occurs in about 1% of eyes with a successful GFS.
o   Risk factors are: thin walled cystic blebs, transconjunctival oozing of aqueous, inferior filtration blebs, blepharitis, CL use, diabetes mellitus, malnutrition and a compromised immune system.

·          
EXTENSIVELY LARGE BLEB=
o   A large bleb may cause a foreign-body sensation. Dellen or bubbles in the tear film may occur anterior to the bleb. Artificial tears or bland ointments can be tried.
o   A symptomatic bleb present 3 months after surgery can be treated with trichloracetic acid or cryotherapy. Autologous blood injection into the bleb can be done. Nd:YAG (3-4 J with offset at 3-4) can be used to put a few shots on the sclera to shrink the bleb. Excision-resuturing is often required.

·        
 PROLAPSE OF UVEAL TISSUE=
o   Deep dissection of the scleral flap entering the supraciliary space can cause postoperative prolapse of uveal tissue through the sclera.

Friday, June 9, 2017

TRABECULECTOMY COMPLICATIONS
(PART 1)

PRE-OPERATIVE CONSIDERATIONS:

  • Stop topical cholinesterase inhibitors (e.g. phospholine iodide) 2-3 weeks before surgery in order to reduce the chances of hyphema and postoperative uveitis.
  • Topical epinephrine products should be stopped 3 days before surgery.
  • Miotics break down the blood-aqueous barrier and should be stopped 2 weeks preoperatively.
  • Steroids: Topical steroids can be started prior to surgery (1-3 weeks before op: Barneby) (2-7 days preop: Pearls of glaucoma management). Oral steroids in appropriate doses can be started in patients with high risk of failure due to inflammation e.g. uveitic-glaucoma.
INTRA-OPERATIVE CONSIDERATIONS:

·         Limbus-based conjunctival flap:
o   Inadvertent injury to extra-ocular muscles and anterior ciliary vessels may occur.
o   Excessive conjunctival manipulation can produce button-holes, thin blebs and lead to scarring.
·         Fornix-based conjunctival flap:
o   There can be difficulty in locating posterior sources of bleeding.
o   There can be increased possibility of aqueous leakage at the limbus (especially if adjunctive anti-metabolites are used)
·         Scleral flap:
o   Be aware of the abrupt change in the curvature of the globe at the limbus to avoid premature entry into the anterior chamber (AC). 

o   It is important to maintain a uniform scleral flap thickness.
o   If the lateral edges of the scleral flap are ‘feathered”, excessive aqueous may leak through poorly apposed wound edges postoperatively.
o   A very thin scleral flap can result in dehiscence, maceration or avulsion during manipulation and suturing. The torn scleral flap can be sutured with 10-0 or 11-0 nylon sutures on a non-cutting needle. A plug of Tenon’s capsule can be sutured to close a scleral buttonhole. If required, a donor scleral or autologous (dura mater or pericardium) graft can be used to close a buttonhole or a new flap needs to be constructed after closing the defect.
·         Conjunctival buttonholes:
o   These can be avoided by limiting dissection with sharp instruments. If a large buttonhole is created early during the procedure, choose a different site for surgery.

o   A 10-0 or 11-0 nylon/polyglactin suture on a non-cutting vascular needle can be used to close the conjunctiva in a shoestring or mattress fashion. Tenon’s capsule can be incorporated into the defect. If the buttonhole is near the limbus the conjunctiva with the hole can be excised, the cornea abraded lightly with a blade and the conjunctiva sutured to the area by 10-0 nylon mattress sutures. A buttonhole noted near the end of the surgery can be closed by an autologous conjunctiva graft from the inferior conjunctiva. Amniotic membrane transplantation is also possible.
·         Hemorrhage:
o   Episcleral bleeding is common, especially those on long-term antiglaucoma medications. Some suggest stopping the topical treatment and putting the patient on Oral Acetazolamide a few days prior to surgery. Damage to the ciliary body can also cause brisk bleeding. Cautery may not work, but intraocular bipolar units on a low setting may be effective. Alternatively, sustained, gentle pressure with a sponge on the fistula or an air bubble in the AC may be attempted. Choroidal/expulsive hemorrhage can result from sudden decompression causing rupture of a choroidal vessel. An immediate inferior temporal scleral incision is practiced by some.
·         Choroidal effusion:
o   It can occur in patients with prominent episcleral vessels, e.g. Sturge-Weber Syndrome. It is characterized by sudden shallowing of AC or rotation of ciliary processes through the iridectomy into the sclerostomy. It is managed by making a scleral incision to release suprachoroidal pressure. 
·         Other complications:
o   Vitreous loss during creation of fistula or iridectomy, due to rupture of lens zonules and hyaloid membrane due to excessive manipulation. It can be managed by vitrectomy (manual or automated). Lens injury and stripping of Descemet’s membrane may occur.
·         Intra-operative suture manipulation to control intra-ocular pressure (IOP):
o   Releasable scleral flap sutures can be applied to prevent sudden lowering of IOP (hypotony) in the postoperative period. The sutures can be removed 1-14 days after surgery.

o   Passage of a needle during suturing can cause intraoperative laceration or disinsertion (amputation) of the scleral flap. Injury to the lens, corneal endothelium or intra-ocular hemorrhage can occur if the needle is misdirected. Scleral flap disinsertion can be avoided by making the flap of atleast 1/3rd scleral thickness. Avoid exposed suture ends or knots as they cause ocular irritation and act as a wick leading to blebitis or endophthalmitis.
o   Scleral flap sutures can also be lysed postoperatively by Argon laser. A topical anesthetic and phenylephrine to constrict the conjunctival vessels can be applied. A Hoskins, Zeiss or Ritch lens can be used. The laser settings are: 50µ spot size, 0.1 second duration and power between 200-600 mW. It may occasionally be difficult to identify the suture due to overlying fibrosis, edema or hemorrhage. Excessive manipulation of the contact lens during laser suturelysis can cause conjunctival damage and buttonholes.

EARLY POST-OPERATIVE COMPLICATIONS:
 (Occur within 4 weeks after surgery)

·         Hyphema:
o   Small intra-operative hyphemas usually resolve within 24-48 hours and rarely require surgical intervention (AC washouts).
·         Iridocyclitis:
o   Postoperative uveitis is a common occurrence. Corticosteroids and possibly cycloplegic agents should be given to avoid formation of posterior synechiae and occlusion of sclerostomy site.
·         Elevated IOP with deep AC:
o   High IOP with a shallow or flat bleb and deep AC in the early postoperative period suggests internal blockage of the sclerostomy or tight scleral flap sutures. Immediate gonioscopy should be done (using a lens with a diameter smaller than cornea, e.g. Zeiss). The sclerostomy can be blocked by: incompletely excised Descemet’s membrane, iris, ciliary processes, ciliary body, lens, lens capsule, fibrin, and vitreous or coagulated blood. Retained viscoelastic, when used to form the AC, may also temporarily raise the IOP. Blood and fibrin clots may also cause occlusion of the sclerostomy but usually resolve with time and ocular massage. Tissue plasminogen activator (TPA) can be used (5-10µ) for intracameral injection to help early lysis of the clot. Entrapped tissue (iris, ciliary processes, lens capsule) can be disrupted with argon or Nd:YAG laser.
o   If the internal ostium is found to be free of obstruction, flap manipulation is required. This can be done by digital massage or pressure to the edge of the scleral flap by a cotton tipped applicator (cotton-bud). The scleral flap sutures should not be removed for the first 2-3 days to avoid over-filtration, hypotony, maculopathy or choroidal detachment among others.
·         Low IOP and shallow AC:
o   Causes are: over-filtration, wound leak, aqueous hyposecretion (temporary ciliary shutdown can occur due to over-cautery) and/or choroidal effusion. Low IOP with shallow AC is common in early postoperative period. The AC is shallowest on day 2-3 and gradually deepens over the next 2 weeks.
o   Postoperative AC depth is graded as follows:
GRADE
FEATURES

Grade 1
Peripheral iris-cornea touch
Usually AC forms simultaneously.
Grade 2
Iris sphincter-cornea touch
Requires conservative measures such as bed rest, cycloplegia, pressure patch, Simmons shell/symblepharon ring/oversized contact lens placement.
Grade 3
Lens-cornea or vitreous-cornea touch
A prolonged (1-2 weeks) Grade 3 AC requires surgical intervention to prevent corneal endothelial cell loss and decompensation, cataract, anterior/posterior synechiae and bleb failure. Viscoelastic injection into the AC can be done as a temporary measure to wait for the spontaneous resolution of the condition.

·         Aqueous hyposecretion= Causes are:  Iridocyclitis, ciliary body detachment, cyclodialysis cleft, postoperative use of topical aqueous suppressants in the operated eye, systemic carbonic anhydarse inhibitors, excessive use of postoperative topical phenylephrine, ciliary body exhaustion from an excessively large sclerostomy or leaking conjunctival wound. This leads to a shallow or flat bleb.
·         Low IOP and deep AC:
o   A low IOP is common in the first week or two after surgery.
·         Over-filtration:
o   It is characterized by an exuberant bleb. Such a bleb can be avoided by releasable sutures. The condition is initially managed by external tamponade (torpedo bandage). Gentamycin eyedrops may help by producing some amount of scarring. Solcoceryl gel may also help. Prolonged overfiltration may require surgically tightening of the scleral flap.
·         Wound leak:
o   Common in the early postoperative period and characterized by a positive Seidel’s test. Non-invasive treatments include: pressure patch, topical antibiotic, aqueous suppressants, Simmon shell or large contact lens. Definitive therapy is surgical closure.
·         Choroidal effusion:
o   Can cause a persistently low IOP and flat AC. This may resolve within 1-2 weeks spontaneously. A persistent flat AC or choroidal hemorrhage requires surgical management. The AC is entered through the old/new paracentesis. An AC maintainer is preferably inserted. Fluid is drained from the inferior temporal quadrant. If the suprachoroidal fluid is excessive, a scleral incision in the same quadrant is required. If eye remains soft or AC doesn’t form, a conjunctival buttonhole should be looked for. The scleral flap should also be tightened by additional sutures. The scleral incision is not sutured and only the overlying conjunctiva is closed with a running absorbable suture.


·         High IOP with shallow AC:
o   This situation may result from:
Pupillary block
Ciliary block (“malignant glaucoma”)
Suprachoroidal hemorrhage

Ø  Pupillary block is rare in presence of a patent peripheral iridectomy.
Ø  Malignant glaucoma (MG) =
o   There is posterior pooling of aqueous within or behind the vitreous. It causes forward movement of the lens-iris or hyaloid-iris diaphragm. The AC is very shallow uniformly or flat. IOP is usually high, unless there is a choroidal detachment and/or functioning filtration bleb. Ultrasound biomicroscopy can show fluid in suprachoroidal space. B-scan will show fluid-filled pockets in vitreous. Risk factors for MG include: Patients with chronic angle closure glaucoma, peripheral anterior synechiae and uncontrolled glaucoma.  It may occur immediately following surgery or after cycloplegic agents are discontinued. If MG occurs in one eye, there is a high risk of the condition developing in the other eye.          
                     
o   Management of MG= Initial management is with topical Atropine 1% (or Scopolamine 0.25%) every 6 hours, topical 2.5% phenylephrine every 6 hours, topical and/or systemic aqueous suppressants and systemic hyperosmotic agents. Nearly 50% of the cases resolve with medical treatment. However, the patients may require cycloplegic therapy for the remainder of their lives.
o   If AC doesn’t form in 3-5 days, further treatment is required. Argon treatment of visible ciliary processes, Nd:YAG anterior hyaloidectomy or posterior capsulotomy in aphakic/pseudophakic eyes is performed. In case above measures fail, then surgical intervention in the form of vitrectomy with rupture of anterior hyaloid face in apahkic/psuedophakic eyes combined with lensectomy in phakic eyes is sufficient.
Ø  Suprachoroidal hemorrhage= It can occur intraoperatively or in the first few postoperative days. It is characterized by: pain, a firm eye, shallow AC and a dark mass visible in the pupil. It is commoner in: old patients with systemic vascular disease and eyes with advanced glaucoma, high pre-operative IOP, aphakia/pseudophakia and eyes which have undergone previous surgical procedures including vitrectomy. Reduction of IOP and control of hypertension prior to surgery may prevent the occurrence of a suprachoroidal hemorrhage. 

·         Loss of central fixation:
o   Early postoperative sudden loss of vision may occur in advanced glaucoma (“snuff-out” or “wipe-out” syndrome).
o   Incidence: <0.5%
o   Patients with extensive glaucomatous damage, a remaining small (≤5 degrees) central island of vision or VF splitting fixation are most susceptible. This wipe out occurs with medical therapy also with equal frequency, so surgical treatment is not a contraindication for surgery.
o   Other causes of visual deterioration include: cystoid macula edema, hyptonic maculopathy, choroidal folds, retinal vascular occlusion and anterior ischemic neuropathy.
·         Retinal complications:
o   Sudden lowering of IOP leads to decompression retinopathy consisting of intraretinal, subretinal and occasional suprachoroidal hemorrhages. Dot and blot hemorrhages mimicking CRVO are present in mid-periphery. Prognosis for visual recovery is usually good. Early postoperative non-rhegmatogenous serous retinal detachment can occur in hypotonous eyes with choroidal detachment. This resolves with normalization of IOP. Persistent surface-wrinkling maculopathy and tears in the retinal pigment epithelium have been reported.
·    
· Postoperative Endophthalmitis (POE): 
o   Early POE is very rare (o.1%).