Friday, September 23, 2016


XEN45 MIGS LAUNCH


  • The Xen45 implant was launched in Malaysia by Allergan at the Conexxion@Nexus in Kuala Lumpur on 22nd September 2016. 
 
  • This Xen45 is designed as a simple Minimally Invasive Glaucoma Surgery (MIGS) implant for mild to moderate glaucomas.

  • Inserted through the cornea, the tube is injected to lie between the anterior chamber and subconjunctival space, where it drains aqueous.

  • Although the procedure looks simple, there seems to be a learning curve involved. 
  • It is also not clear what complications commonly occur and of course, the long term results are yet to be known. 

  • According to Dr Chelvin Sng, nearly 20% of the cases require needling at some stage.

  • It can be done during phacoemulsification as a one step procedure.

  • (A suggestion: Would injection of a little BSS in the area where the Xen is supposed to come out, to balloon the conjunctiva, reduce the rates of conjunctival perforation ?) 

  • The Xen45 will be available in the Malaysian market by next year.
https://www.youtube.com/watch?v=eH08bedOPn4&spfreload=5

Saturday, September 17, 2016

GONIOSCOPY: MADE EASY
(REVISED)

Alexios Trantas, in 1907, first used the term“gonioscopy”, from the Greek origins on gonia meaning “angle” and skopein to “observe”. Maximilian Salzmann was the first to use a contact lens and indirect gonioscopy for examination of the angle. Therefore, both Trantas and Salzmann are regarded as the “fathers of gonioscopy”.


Principle of gonioscopy:

When light passes from a medium with greater index of refraction to a medium with lower index of refraction, the angle of refraction (r) is greater than the angle of incidence (i).

The angle of incidence (i) reaches critical angle when r is equal to 900.

If the angle of incidence (i) is more than critical angle, the light is reflected back into the first medium. (Total internal reflection)

The critical angle for the cornea-air interface is approximately 400.

Light rays coming from the angle of the anterior chamber exceed the critical angle and are therefore reflected back into the AC (anterior chamber). This prevents visualization of the AC angle.


This deficiency can be overcome by optically replacing the cornea with another interface.
The refractive index of the contact lens is the same as that of the corneal epithelium so that there is minimal refraction at the interface of these 2 surfaces (Contact lens-cornea). This removes the optical effect of cornea.

The light rays from the AC angle reach the contact lens. Subsequently, they are made to pass through the new "contact lens-air" interface.
In direct gonioscopy (gonio-lens) the anterior curve of the contact lens is such that the critical angle is not reached. The light rays are refracted at the contact lens-air interface to the observer’s eye.
In indirect gonioscopy, the light rays are reflected by a mirror in the contact lens (gonio-prism). The light rays leave the lens at nearly a right angle to the contact lens-air interface.




INDIRECT GONIOSCOPY:



Goldmann single-mirror contact lens
Mirror height= 12mm
Mirror tilt= 620
Goldmann 3-mirror
Semicircular mirror
590
Zeiss 4-mirror

640
Ritch trabeculoplasty 4-mirror lens

2 tilted= 590
2 tilted= 620


Procedure:

  • Use minimal room illumination.
  • Shorten slit beam as much as possible. Do not throw light into the pupil.
  • Use high magnification.
  • Keep beam off-centre at 30-350.
  • Place lens gently on the eye with patient looking up. Once the lens is in place ask patient to look straight.
  • Stop moving the lens when you can view the iris. (Furrows)
  •  

From Kanski

Now move the beam towards the periphery. In myopes, aphakia/pseudophakia you can see the ciliary body. It appears as a pink, dull brown or slate grey band.

The scleral spur is the posterior lip of the scleral sulcus. It appears as a prominent white line between the dark ciliary body band and the pigmented trabecular meshwork.

Fine, pigmented strands frequently cross the scleral spur. They run from the iris root to the pigmented trabecular meshwork and are called “iris processes”. (They represent thickenings of the posterior uveal meshwork).They might be confused with peripheral anterior synechiae and need dynamic gonioscopy for confirmation.


Anterior to the scleral spur is the functional trabecular meshwork. It is seen as a pigmented band just anterior to the scleral spur.


The junction of the angle structures and cornea is called Schwalbe’s line. It is the peripheral termination of Descemet’s membrane. It appears as a fine ridge or opaque line. In highly pigmented eyes, it can be pigmented, especially inferiorly.



GRADES OF ANGLE WIDTH:

 (Modified from Clinical Ophthalmology: A systemic approach, Jack J Kanski, 6th ed.)


GRADE 4
350-450
Ciliary body visible.
Seen in myopia, aphakia, pseudophakia.
Incapable of closure.
GRADE 3
250-350
Scleral spur visible.

Incapable of closure.
GRADE 2
200
Trabecular meshwork visible.
Moderately narrow angle.
Angle closure possible but unlikely.
GRADE 1
100
Schwalbe’s line visible.
Very narrow angle.
Angle closure not inevitable, but risk is high.
SLIT ANGLE

No obvious irido-corneal contact. However, no angle structures can be identified.

High risk of imminent closure.
GRADE 0
00
Iridocorneal contact present. Inability to identify the apex of corneal wedge.
Closed angle.
Indentation gonioscopy is required to differentiate appositional from synechial angle closure.


Dynamic Gonioscopy (Compression or indentation gonioscopy):

  • Pressure is applied on the cornea with contact lens, this pushes aqueous into the AC angle.
  • This opens up the angle.
  • In case of peripheral anterior synechiae (synechial closure) the angle may not open but will open up if only iris processes are present or the cornea and angle structures are in close approximation (appositional closure).
GONIOSCOPY FLOW CHART:

Acknowledgment:
Some of the pictures have been taken from: Gonioscopy by Christoph Faschinger & Anton Hommer. Springer publications.